White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

ABSTRACT:

Background

Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.

Objectives

To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year Finnish Geriatric Intervention Study to prevent Cognitive Impairment and Disability (FINGER), a randomized controlled trial in at-risk older individuals (age 60-77 years) from the general population.

Methods

This exploratory study consisted of a subsample of 60 FINGER participants. Participant

SUBMITTER: Stephen R 

PROVIDER: S-EPMC7683078 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature