Cognitive, Genetic, Brain Volume, and Diffusion Tensor Imaging Markers as Early Indicators of Dementia.

ABSTRACT:

Background

Although associated with dementia and cognitive impairment, microstructural white matter integrity is a rarely used marker of preclinical dementia.

Objective

We aimed to evaluate the individual and combined effects of multiple markers, with special focus on microstructural white matter integrity, in detecting individuals with increased dementia risk.

Methods

A dementia-free subsample (n = 212, mean age = 71.33 years) included in the population-based Swedish National Study on Aging and Care (SNAC-K) underwent magnetic resonance imaging (T1-weighted, fluid-attenuated inversion recovery, diffusion tensor imaging), neuropsychological testing (perceptual speed, episodic memory, semantic memory, letter and category fluency), and genotyping (APOE). Incident dement

SUBMITTER: Muller T 

PROVIDER: S-EPMC7683082 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature