Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review.

ABSTRACT:

Background

Cognitive aging is a dynamic process in late life with significant heterogeneity across individuals.

Objective

To review the evidence for latent classes of cognitive trajectories and to identify the associated predictors and outcomes.

Methods

A systematic search was performed in MEDLINE and EMBASE for articles that identified two or more cognitive trajectories in adults. The study was conducted following the PRISMA statement.

Results

Thirty-seven studies were included, ranging from 219 to 9,704 participants, with a mean age of 60 to 93.4 years. Most studies (n = 30) identified distinct cognitive trajectories using latent class growth analysis. The trajectory profile commonly consisted of three to four classes with progressively decreasing base

SUBMITTER: Wu Z 

PROVIDER: S-EPMC7683100 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature