eys ^+/- ; lrp5 ^+/- Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle.

ABSTRACT: Vision is essential for vertebrates including humans. Sustained vision is accomplished by retinoid metabolism, the "visual cycle," where all-trans retinol (atROL) is incorporated into the retinal pigment epithelium (RPE) from photoreceptors presumably through decade-long missing receptor(s). Here, we show that the LDL-related receptor-5 (Lrp5) protein is linked to the retinol binding protein 1a (Rbp1a), the transporter of atROL in the visual cycle, by generating and analyzing the digenic eyes shut homolog ^+/- ; lrp5 ^+/- zebrafish, the same form of gene defect detected in a human case of inherited retinal degeneration. Global gene expression analysis followed by genetic study clarified that rbp1a played a role downstream of

SUBMITTER: Takita S 

PROVIDER: S-EPMC7683268 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature