Pseudomonas aeruginosa virulence proteins pseudolysin and protease IV impede cutaneous wound healing.

ABSTRACT: The intricate biological process of cutaneous wound healing is achieved through precise and highly programmed events. Dermal fibroblasts and keratinocytes play a significant role in the process of reepithelialization during wound healing. Pathogenic bacteria such as Pseudomonas aeruginosa (P. aeruginosa) may delay the proliferative phase of wound repair by secreting their proteins leading to delayed or impaired wound healing. We have analyzed three virulent strains of P. aeruginosa isolated from the wound environment which also differed in their ability to produce biofilms. Mass spectrometric analysis of differentially expressed secreted proteins by three virulent strains of P. aeruginosa revealed peptides from pseudolysin and protease IV expressed from lasB and prpL genes. Pseudolysin and

SUBMITTER: Prasad ASB 

PROVIDER: S-EPMC7683349 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature