Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.

ABSTRACT: Hematopoiesis, the complex developmental process that forms blood components and replenishes the blood system, involves multiple intracellular and extracellular mechanisms. We previously demonstrated that lysophosphatidic acid (LPA), a lipid growth factor, has opposing regulatory effects on erythrocyte differentiation through activation of LPA receptors 2 and 3; yet the mechanisms underlying this process remain unclear. In this study, LPA₂ is observed that highly expressed in common myeloid progenitors (CMP) in murine myeloid cells, whereas the expression of LPA₃ displaces in megakaryocyte-erythroid progenitors (MEP) of later stage of myeloid differentiation. Therefore, we hypothesized that the switching expression of LPA₂ and LPA₃ determine the

SUBMITTER: Chiang JC 

PROVIDER: S-EPMC7683362 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature