The Role of the Gut Microbiome in Resisting Norovirus Infection as Revealed by a Human Challenge Study.

ABSTRACT: Norovirus infections take a heavy toll on worldwide public health. While progress has been made toward understanding host responses to infection, the role of the gut microbiome in determining infection outcome is unknown. Moreover, data are lacking on the nature and duration of the microbiome response to norovirus infection, which has important implications for diagnostics and host recovery. Here, we characterized the gut microbiomes of subjects enrolled in a norovirus challenge study. We analyzed microbiome features of asymptomatic and symptomatic individuals at the genome (population) and gene levels and assessed their response over time in symptomatic individuals. We show that the preinfection microbiomes of subjects with asymptomatic infections were enriched in Bacteroidetes and

SUBMITTER: Patin NV 

PROVIDER: S-EPMC7683401 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature