Novel Potential Biomarker of Adult Cardiac Surgery-Associated Acute Kidney Injury.

ABSTRACT:

Background

Acute kidney injury (AKI) occurs in about 30% of patients with cardiac surgery, but the pathogenesis of cardiac surgery-associated acute kidney injury (CSA-AKI) remains unclear and there are no predictive biomarkers or diagnostic criteria specific for CSA-AKI beyond the general clinical variables for AKI like serum creatinine (SCr).

Methods and results

We measured the plasma levels of 48 cytokines within 24 h after cardiac surgery in a total of 306 adult patients including 204 with and 102 without AKI, and then evaluated the diagnostic efficacy of these cytokines for the development of CSA-AKI via ANOVA and Pearson correlation analysis. Among these 48 cytokines, 20 of them were significantly different in the AKI patients compared with the non-AKI patients. In part

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7683426 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature