Application of an open-chamber multi-channel microfluidic device to test chemotherapy drugs.

ABSTRACT: The use of precision medicine for chemotherapy requires the individualization of the therapeutic regimen for each patient. This approach improves treatment efficacy and reduces the probability of administering ineffective drugs. To ensure accurate decision-making in a timely manner, anticancer drug efficacy tests must be performed within a short timeframe using a small number of cancer cells. These requirements can be satisfied via microfluidics-based drug screening platforms, which are composed of complex fluidic channels and closed systems. Owing to their complexity, skilled manipulation is required. In this study, we developed a microfluidic platform, to accurately perform multiple drug efficacy tests using a small number of cells, which can be conducted via simple manipulation. As it i

SUBMITTER: Moon HS 

PROVIDER: S-EPMC7683738 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature