Assessment of population-based input functions for Patlak imaging of whole body dynamic ¹⁸F-FDG PET.

ABSTRACT:

Background

Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic ¹⁸F-FDG PET imaging. However, this procedure is invasive and not typically available in clinical environments. As an alternative, we compared AIFs to population-based input functions (PBIFs) using two normalization methods: area under the curve (AUC) and extrapolated initial plasma concentration (C_P*(0)). To scale the PBIFs, we tested two methods: (1) the AUC of the image-derived input function (IDIF) and (2) the estimated C_P*(0). The aim of this study was to validate IDIF and PBIF for FDG oncological WB PET studies by comparing to the gold standard arterial blood sampling.

Methods

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SUBMITTER: Naganawa M 

PROVIDER: S-EPMC7683759 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature