Direct comparison of brain [¹⁸F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies.

ABSTRACT:

Background

Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the advantages of SiPM-PET in ¹⁸F-fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) brain imaging in a head-to-head comparison with PMT-PET in phantom and clinical studies.

Methods

Contrast was calculated from images acquired from a Hoffman 3D brain phantom, and image noise and uniformity were calculated from images acquired from a pool phantom using SiPM- and PMT-PET. Sequential PMT-PET and SiPM-PET [¹⁸F]FDG images were acquired over a period of 10 min from 22 controls and 10 patients. All images were separately normalized to a standard [^18<

SUBMITTER: Wagatsuma K 

PROVIDER: S-EPMC7683764 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature