Prognostic and Predictive Value of an Immunoscore Signature in Glioblastoma Multiform.

ABSTRACT:

Background

Although increasing evidence shows that immune infiltration plays an essential role in glioblastoma (GBM), current prognostic indicators do not accurately represent the risk of immune cells infiltration in patients. It is therefore critical to identify new prognostic markers for GBM. Here, we investigated the effectiveness of using immunoscore to improve risk stratification and prediction of prognosis in GBM patients receiving chemotherapy.

Methods

Using mRNA microarrays and CIBERSORT, we analyzed 22 types of immune cell fractions in 517 GBM samples and characterized an immunoscore using the least absolute shrinkage and selection operator (LASSO) Cox regression model based on the fraction of immune cell types and patients' overall survival. The prognostic and pred

SUBMITTER: Tang X 

PROVIDER: S-EPMC7684008 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature