Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia.

ABSTRACT: Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted cognitive training (TCT) is a "bottom-up" cognitive remediation intervention with efficacy for neurocognitive outcomes in schizophrenia, yet individual responses are variable. Gamma oscillatory measures are leading candidate biomarkers in the development of biologically informed pro-cognitive therapeutics. Forty-two schizophrenia patients were recruited from a long-term residential treatment facility. Participants were randomized to receive either 1 h of cognitive training (TCT, n = 21) or computer games (TAU, n = 21). All participants received standard-of-care treatment; the TCT group additionally completed 30 h of cognitive training. The auditory steady-state response paradigm was used to elicit gamma o

SUBMITTER: Molina JL 

PROVIDER: S-EPMC7684295 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature