Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery.

ABSTRACT: Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating weight loss and resolving associated comorbidities. VSG in humans is a complex procedure and includes peri-operative antibiotics and caloric restriction in addition to the altered anatomy. The impact of each of these factors on the intestinal microbiota have not been evaluated. The aim of this study was to determine the relative contributions of each of these factors on intestinal microbiota composition following VSG prior to substantial weight loss. Thirty-two obese patients

SUBMITTER: Nalluri H 

PROVIDER: S-EPMC7684314 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature