Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment.

ABSTRACT: Human biomonitoring (HBM) data can provide insight into co-exposure patterns resulting from exposure to multiple chemicals from various sources and over time. Therefore, such data are particularly valuable for assessing potential risks from combined exposure to multiple chemicals. One way to interpret HBM data is establishing safe levels in blood or urine, called Biomonitoring Equivalents (BE) or HBM health based guidance values (HBM-HBGV). These can be derived by converting established external reference values, such as tolerable daily intake (TDI) values. HBM-HBGV or BE values are so far agreed only for a very limited number of chemicals. These values can be established using physiologically based kinetic (PBK) modelling, usually requiring substance specific models and the collection of

SUBMITTER: Pletz J 

PROVIDER: S-EPMC7684529 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature