Ontology highlight
ABSTRACT:
SUBMITTER: Singh N
PROVIDER: S-EPMC7684646 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Singh Nathan N Orlando Elena E Xu Jun J Xu Jie J Binder Zev Z Collins McKensie A MA O'Rourke Donald M DM Melenhorst J Joseph JJ
Seminars in cancer biology 20191219
Chimeric antigen receptor (CAR)-engineered T cells have demonstrated remarkable success in the treatment of B cell malignancies. FDA approval of these therapies represents a watershed moment in the development of therapies for cancer. Despite the successes of the last decade, many patients will unfortunately not experience durable responses to CAR therapy. Emerging research has shed light on the biology responsible for these failures, and further highlighted the hurdles to broader success. Here, ...[more]