CusVarDB: A tool for building customized sample-specific variant protein database from next-generation sequencing datasets.

ABSTRACT: Cancer genome sequencing studies have revealed a number of variants in coding regions of several genes. Some of these coding variants play an important role in activating specific pathways that drive proliferation. Coding variants present on cancer cell surfaces by the major histocompatibility complex serve as neo-antigens and result in immune activation. The success of immune therapy in patients is attributed to neo-antigen load on cancer cell surfaces. However, which coding variants are expressed at the protein level can't be predicted based on genomic data. Complementing genomic data with proteomic data can potentially reveal coding variants that are expressed at the protein level. However, identification of variant peptides using mass spectrometry data is still a challenging task due t

SUBMITTER: Kasaragod S 

PROVIDER: S-EPMC7684676 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature