Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain.

ABSTRACT:

Background

Mild traumatic brain injury (mTBI) has a higher prevalence (more than 50%) of developing chronic posttraumatic headache (CPTH) compared with moderate or severe TBI. However, the underlying neural mechanism for CPTH remains unclear. This study aimed to investigate the inflammation level and cortical volume changes in patients with acute PTH (APTH) and further examine their potential in identifying patients who finally developed CPTH at follow-up.

Methods

Seventy-seven mTBI patients initially underwent neuropsychological measurements, 9-plex panel of serum cytokines and MRI scans within 7 days post-injury (T-1) and 54 (70.1%) of patients completed the same protocol at a 3-month follow-up (T-2). Forty-two matched healthy controls completed the same protocol at T-1 on

SUBMITTER: Niu X 

PROVIDER: S-EPMC7684719 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature