Transgenerational effect of drug-mediated inhibition of LSD1 on eye pigment expression in Drosophila.

ABSTRACT:

Background

The Drosophila melanogaster mutant white-mottled is a well-established model for position-effect variegation (PEV). Transposition of the euchromatic white gene into the vicinity of the pericentric heterochromatin caused variegated expression of white due to heterochromatin spreading. The establishment of the euchromatin-heterochromatin boundary and spreading of silencing is regulated by mutually exclusive histone modifications, i.e. the methylations of histone H3 at lysine 9 and lysine 4. Demethylation of H3K4, catalysed by lysine-specific demethylase LSD1, is required for subsequent methylation of H3K9 to establish heterochromatin. LSD1 is therefore essential for heterochromatin formation and spreading. We asked whether drug-mediated inhibition of LSD affects the expres

SUBMITTER: Hoyer-Fender S 

PROVIDER: S-EPMC7684728 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature