Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis.

ABSTRACT:

Background

Sustained DMARD-free remission (SDFR) is increasingly achievable. The pathogenesis underlying SDFR development is unknown and patient characteristics at diagnosis poorly explain whether SDFR will be achieved. To increase the understanding, we studied the course of disease activity scores (DAS) over time in relation to SDFR development. Subsequently, we explored whether DAS course could be helpful identifying RA patients likely to achieve SDFR.

Methods

772 consecutive RA patients, promptly treated with csDMARDs (mostly methotrexate and treat-to-target treatment adjustments), were studied for SDFR development (absence of synovitis, persisting minimally 12 months after DMARD stop). The course of disease activity scores (DAS) was compared between RA patients with and

SUBMITTER: Verstappen M 

PROVIDER: S-EPMC7684730 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature