Lrp4 in hippocampal astrocytes serves as a negative feedback factor in seizures.

ABSTRACT:

Background

Epilepsy is characterized by the typical symptom of seizure, and anti-seizure medications are the main therapeutic method in clinical, but the effects of these therapy have not been satisfactory. To find a better treatment, it makes sense to further explore the regulatory mechanisms of seizures at genetic level. Lrp4 regionally expresses in mice hippocampus where is key to limbic epileptogenesis. It is well known that neurons release a high level of glutamate during seizures, and it has been reported that Lrp4 in astrocytes down-regulates glutamate released from neurons. However, it is still unclear whether there is a relationship between Lrp4 expression level and seizures, and whether Lrp4 plays a role in seizures.

Results

We found that seizures induced by piloca

SUBMITTER: Yu Z 

PROVIDER: S-EPMC7684739 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature