Bioinformatics analysis of the microRNA-mRNA network in sebaceous gland carcinoma of the eyelid.

ABSTRACT: Sebaceous gland carcinoma (SGC) of the eyelid is an uncommon aggressive tumor with a relatively high rate of local recurrence and a poor prognosis following metastasis. However, the molecular mechanisms underlying the pathogenesis of SGC remain unclear. The purpose of the present study was to clarify microRNA (miRNA) expression profiles in SGC and to explore novel miRNA‑mRNA networks of SGC. A small RNA‑sequencing analysis was performed to identify miRNAs differentially expressed between SGC and sebaceous adenoma control samples. Bioinformatics analyses were conducted to reveal biological functions, canonical pathways and molecular interaction networks using integrated miRNA‑mRNA datasets, including mRNA expression profiles of SGC from our previous study. The present results demonstrated t

SUBMITTER: Hirano T 

PROVIDER: S-EPMC7684873 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature