The impact of lifecourse socio-economic position and individual social mobility on breast cancer risk.

ABSTRACT:

Background

Women with an advantaged socioeconomic position (SEP) have a higher risk of developing breast cancer (BC). The reasons for this association do not seem to be limited to reproductive factors and remain to be understood. We aimed to investigate the impact of lifecourse SEP from childhood and social mobility on the risk of BC considering a broad set of potential mediators.

Methods

We used a discovery-replication strategy in two European prospective cohorts, E3N (N = 83,436) and EPIC-Italy (N = 20,530). In E3N, 7877 women were diagnosed with BC during a median 24.4 years of follow-up, while in EPIC-Italy, 893 BC cases were diagnosed within 15.1 years. Hazard ratios (HR) were estimated using Cox proportional hazard models on imputed data.

Results

In E3N, women w

SUBMITTER: Berger E 

PROVIDER: S-EPMC7684912 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature