FABP7 is a potential biomarker to predict response to neoadjuvant chemotherapy for breast cancer.

ABSTRACT:

Background

Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought to identify potential biomarkers to predict the response to neoadjuvant chemotherapy for breast cancer patients.

Methods

Three genomic profiles acquired by microarray analysis from subjects with or without residual tumors after NAC downloaded from the GEO database were used to screen the differentially expressed genes (DEGs). An array of public databases, including ONCOMINE, cBioportal, Breast Cancer Gene Expression Miner v4.0, and the Kaplan Meir-plotter, etc., were used to evaluate the potential functions, related signaling pathway, as well as prognostic values of FABP7 in

SUBMITTER: Xie Q 

PROVIDER: S-EPMC7684949 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature