A population of CD4^hiCD38^hi T cells correlates with disease severity in patients with acute malaria.

ABSTRACT:

Objective

CD4⁺ T cells are critical mediators of immunity to Plasmodium spp. infection, but their characteristics during malarial episodes and immunopathology in naturally infected adults are poorly defined. Flow cytometric analysis of PBMCs from patients with either P. falciparum or P. knowlesi malaria revealed a pronounced population of CD4⁺ T cells co-expressing very high levels of CD4 and CD38 we have termed CD4^hiCD38^hi T cells. We set out to gain insight into the function of these novel cells.

Methods

CD4⁺ T cells from 18 patients with P. falciparum or P. knowlesi malaria were assessed by flow cytometry and sorted into populations of CD4^hiCD38^hi or CD4^nor

SUBMITTER: Apte SH 

PROVIDER: S-EPMC7684974 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature