Involvement of activated cytotoxic T lymphocytes and natural killer cells in Henoch-Schonlein purpura nephritis.

ABSTRACT:

Objectives

Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a major cause of vasculitis in children. It is often accompanied by nephritis (HSPN) and could progress to chronic kidney disease. Galactose-deficient IgA₁ was recently reported to be involved in the pathogenesis of HSPN, for which immunosuppressive drugs are considered key treatment. However, the involvement of immune cells in the development of HSPN remains unclear.

Methods

We compared gene expressions of peripheral blood mononuclear cells (PBMCs) among healthy controls (n = 10), IgAV/HSP patients (n = 21) and HSPN patients (n = 8), which required nephritis development within 3 months of IgAV/HSP onset. Immunohistochemistry analysis and flow cytometry were performe

SUBMITTER: Imai T 

PROVIDER: S-EPMC7684975 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature