Effects of the vibrating capsule on colonic circadian rhythm and bowel symptoms in chronic idiopathic constipation.

ABSTRACT:

Background

Constipated patients remain dissatisfied with current treatments suggesting a need for alternative therapies.

Aim

Evaluate the mechanistic effects of oral vibrating capsule in chronic idiopathic constipation (CIC) by examining the temporal relationships between the onset of vibrations, complete spontaneous bowel movements (CSBM), and circadian rhythm.

Methods

In post hoc analyses of two double-blind studies, CIC patients (Rome III) were randomized to receive 5 active or sham capsules/week for 8 weeks. The capsules were programmed for single vibration (study 1) or two vibration sessions with two modes, 8 hours apart (study 2). Daily electronic diaries assessed stool habit and percentage of CSBMs associated with vibrations. Responders were patients with ≥ 1 C

SUBMITTER: Rao SSC 

PROVIDER: S-EPMC7685128 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature