Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response.

ABSTRACT:

Objective

To determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.

Design

A retrospective cohort study of healthcare workers who had self-isolated due to COVID-19.

Setting

University Hospitals Birmingham NHS Foundation Trust, UK (UHBFT).

Participants

956 health care workers were recruited by open invitation via UHBFT trust email and social media.

Intervention

Participants volunteered a venous blood sample that was tested for the presence of anti-SARS-CoV-2 spike glycoprotein antibodies. Results were interpreted in the context of the symptoms of their original illness and ethnodemographic variables.

Results

Using an assay that simultaneously measure

SUBMITTER: Shields AM 

PROVIDER: S-EPMC7685342 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature