Clinical factors as prognostic variables among molecular subgroups of endometrial cancer.

ABSTRACT:

Background

Clinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes among molecular subgroups of endometrial cancer.

Methods

This was a single institution retrospective study of patients who underwent surgery for endometrial carcinoma between January 2007 and December 2012. Tumors were classified into four molecular subgroups by immunohistochemistry of mismatch repair (MMR) proteins and p53, and sequencing of polymerase-ϵ (POLE). Overall, cancer-related, and non-cancer-related mortality were estimated using univariable and multivariable survival analyses.

Results

Age >65 years was associated with increased mortality rates in the whole cohort (n = 515) and in the "no

SUBMITTER: Kolehmainen A 

PROVIDER: S-EPMC7685425 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature