Unifying the mechanism of mitotic exit control in a spatiotemporal logical model.

ABSTRACT: The transition from mitosis into the first gap phase of the cell cycle in budding yeast is controlled by the Mitotic Exit Network (MEN). The network interprets spatiotemporal cues about the progression of mitosis and ensures that release of Cdc14 phosphatase occurs only after completion of key mitotic events. The MEN has been studied intensively; however, a unified understanding of how localisation and protein activity function together as a system is lacking. In this paper, we present a compartmental, logical model of the MEN that is capable of representing spatial aspects of regulation in parallel to control of enzymatic activity. We show that our model is capable of correctly predicting the phenotype of the majority of mutants we tested, including mutants that cause proteins to mislocal

SUBMITTER: Howell RSM 

PROVIDER: S-EPMC7685450 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature