Performance and enhancement of the LZerD protein assembly pipeline in CAPRI 38-46.

ABSTRACT: We report the performance of the protein docking prediction pipeline of our group and the results for Critical Assessment of Prediction of Interactions (CAPRI) rounds 38-46. The pipeline integrates programs developed in our group as well as other existing scoring functions. The core of the pipeline is the LZerD protein-protein docking algorithm. If templates of the target complex are not found in PDB, the first step of our docking prediction pipeline is to run LZerD for a query protein pair. Meanwhile, in the case of human group prediction, we survey the literature to find information that can guide the modeling, such as protein-protein interface information. In addition to any literature information and binding residue prediction, generated docking decoys were selected by a rank aggregati

SUBMITTER: Christoffer C 

PROVIDER: S-EPMC7685511 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature