Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis.

ABSTRACT:

Background

Exposure to adverse social factors has been associated with an altered inflammatory profile, a risk factor for several acute and chronic diseases. Differential gene expression may be a biological mediator in the relationship. In this study, associations between a range of social factors and expression of inflammation-related genes were investigated.

Methods

Social factor and gene expression data were collected from 1,264 individuals in the Multi-Ethnic Study of Atherosclerosis (MESA). Inflammation-related genes were identified from the Gene Ontology database. The associations between social factors and gene expression were first assessed using the Global Analysis of Covariance (Global ANCOVA) gene set enrichment test. When the global test was significant, linear r

SUBMITTER: Brown KM 

PROVIDER: S-EPMC7685527 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature