Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function.

ABSTRACT:

Background

Early microbial colonization triggers processes that result in intestinal maturation and immune priming. Perinatal factors, especially those associated with birth, including both mode and place of delivery are critical to shaping the infant gut microbiota with potential health consequences.

Methods

Gut microbiota profile of 180 healthy infants (n = 23 born at home and n = 157 born in hospital, 41.7% via cesarean section [CS]) was analyzed by 16S rRNA gene sequencing at birth, 7 days, and 1 month of life. Breastfeeding habits and infant clinical data, including length, weight, and antibiotic exposure, were collected up to 18 months of life. Long-term personalized in vitro models of the intestinal epithelium and innate immune system were used to assess the link betw

SUBMITTER: Selma-Royo M 

PROVIDER: S-EPMC7685601 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature