Variation under domestication in animal models: the case of the Mexican axolotl.

ABSTRACT:

Background

Species adaptation to laboratory conditions is a special case of domestication that has modified model organisms phenotypically and genetically. The characterisation of these changes is crucial to understand how this variation can affect the outcome of biological experiments. Yet despite the wide use of laboratory animals in biological research, knowledge of the genetic diversity within and between different strains and populations of some animal models is still scarce. This is particularly the case of the Mexican axolotl, which has been bred in captivity since 1864.

Results

Using gene expression data from nine different projects, nucleotide sequence variants were characterised, and distinctive genetic background of the experimental specimens was uncovered. This s

SUBMITTER: Torres-Sanchez M 

PROVIDER: S-EPMC7685626 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature