Improving hard palate wound healing using immune modulatory autotherapies.

ABSTRACT: Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Despite this, injuries to the mucosal surface often heal faster than cutaneous wounds and leave less noticeable scars. Patients undergoing cleft palate repair have a high degree of wound healing complications with up to 60% experiencing oronasal fistula (ONF) formation. In this study, we developed a mouse model of hard palate mucosal injury, to study the endogenous injury response during oral cavity wound healing and ONF formation. Immunophenotyping of the inflammatory infiltrate following hard palate injury showed delayed recruitment of non-classical LY6C^lo monocytes and failure to resolve inflammation. To induce a pro-regenerative inflammatory response, delivery of

SUBMITTER: Ballestas SA 

PROVIDER: S-EPMC7685787 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature