Comparative Pharmacodynamics Study of 3 Different Botulinum Toxin Type A Preparations in Mice.

ABSTRACT:

Background

A new complexing protein-free botulinum toxin Type A (CBoNT) with the same mechanism of action as the botulinum toxin complex onabotulinumtoxinA (OBoNT) and complexing protein-free incobotulinumtoxinA (IBoNT) was recently developed.

Objective

To compare the local paresis and chemodenervation efficacy of 3 different botulinum toxin Type A preparations in mice.

Materials and methods

Efficacy and duration of action of CBoNT, OBoNT, and IBoNT after a single intramuscular injection to the right gastrocnemius was evaluated by digit abduction score (DAS) and compound muscle action potential (CMAP) assays.

Results

Mouse DAS and CMAP responses were comparable between CBoNT and OBoNT, indicating similar paresis and chemodenervation efficacy, as well as duratio

SUBMITTER: Kwak S 

PROVIDER: S-EPMC7685929 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature