A Possible Association Between Executive Dysfunction and Frailty in Patients With Neurocognitive Disorders.

ABSTRACT: Frailty is an age-related dynamic status, characterized by a reduced resistance to stressors due to the cumulative decline of multiple physiological systems. Several researches have highlighted a relationship between physical frailty and cognitive decline; however, the role of specific cognitive domains has not been deeply clarified yet. Current studies have hypothesized that physical frailty and neuropsychological deficits may share systemic inflammation and increased oxidative stress in different neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. However, the role of the executive dysfunction should be investigated in a more detailed way using a multidimensional approach. With this aim, we conducted a review of the literature on the few experimental articles publis

SUBMITTER: Bartoli M 

PROVIDER: S-EPMC7685991 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature