Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans.

ABSTRACT: Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments. One of the causes of therapeutic failures is the acquisition of antifungal resistance by mutations in the C. albicans genome. Fluconazole (FLC) is one of the most widely used antifungal and mechanisms of FLC resistance occurring by mutations have been extensively investigated. However, some clinical isolates are known to be able to survive at high FLC concentrations without acquiring resistance mutations, a phenotype known as tolerance. Mechanisms behind FLC tolerance are not well studied, mainly due to the lack of a proper way to identify and quantify toleranc

SUBMITTER: Delarze E 

PROVIDER: S-EPMC7686038 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature