Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities.

ABSTRACT: Strokes are feared complications of sickle cell disease (SCD) and yield significant neurologic and neurocognitive deficits. However, even without detectable strokes, SCD patients have significant neurocognitive deficits in domains of learning and memory, processing speed and executive function. In these cases, mechanisms unrelated to major cerebrovascular abnormalities likely underlie these deficits. While oxidative stress and stress-related signaling pathways play a role in SCD pathophysiology, their role in cerebral injury remains unknown. We have shown that Townes and BERK SCD mice, while not having strokes, recapitulate neurocognitive deficits reported in humans. We hypothesized that cognitive deficits in SCD mice are associated with cerebral oxidative stress. We showed that SCD mice h

SUBMITTER: Khaibullina A 

PROVIDER: S-EPMC7686096 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature