Screening non-MAPT genes of the Chr17q21 H1 haplotype in Parkinson's disease.

ABSTRACT:

Introduction

The microtubule-associated protein tau (MAPT) gene is considered a strong genetic risk factor for Parkinson's disease (PD) in Caucasians. MAPT is located within an inversion region of high linkage disequilibrium designated as H1 and H2 haplotype, and contains eight other genes which have been implicated in neurodegeneration. The aim of the current study was to identify common coding variants in strong linkage disequilibrium (LD) within the associated loci on chr17q21 harboring MAPT.

Methods

Sanger sequencing of coding exons in 90 Caucasian late-onset PD (LOPD) patients was performed. Specific gene sequencing for LRRC37A, LRRC37A2, ARL17A and ARL17B was not possible given the high homology, presence of pseudogenes and copy number variants that are in the region,

SUBMITTER: Soto-Beasley AI 

PROVIDER: S-EPMC7686230 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature