¹⁸F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.

ABSTRACT:

Objective

This study sought to determine whether ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography could be applied to a murine model of advanced atherosclerotic plaque vulnerability to detect response to therapeutic intervention and changes in lesion stability. Approach and Results: To analyze plaques susceptible to rupture, we fed ApoE^-/- mice a high-fat diet and induced vulnerable lesions by cast placement over the carotid artery. After 9 weeks of treatment with orthogonal therapeutic agents (including lipid-lowering and proefferocytic therapies), we assessed vascular inflammation and several features of plaque vulnerability by ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography and histopathology, respec

SUBMITTER: Jarr KU 

PROVIDER: S-EPMC7686289 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature