Th17-related mammary immunity, but not a high systemic Th1 immune response is associated with protection against E. coli mastitis.

ABSTRACT: Vaccination against bovine mastitis lags behind despite high demand from the dairy industry and margin for efficacy improvement. We previously compared two immunization protocols against E. coli using either only the intramuscular route or a combination of intramuscular and mammary ductal routes, also known as 'prime and pull' strategy. A homologous mammary challenge during the memory phase showed that immunization favorably modified the mastitis course, notably in locally immunized cows in comparison to intramuscular and control adjuvant-only groups. Here, we performed whole-blood profiling through RNA-seq transcriptome and plasma cytokine 15-plex analyses at time points of the E. coli mastitis that showed significant clinical and laboratory differences among the groups. Diminished produc

SUBMITTER: Cebron N 

PROVIDER: S-EPMC7686320 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature