Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase.

ABSTRACT: Leishmaniasis, a major neglected tropical disease, affects millions of individuals worldwide. Among the various clinical forms, visceral leishmaniasis (VL) is the deadliest. Current antileishmanial drugs exhibit toxicity- and resistance-related issues. Therefore, advanced chemotherapeutic alternatives are in demand, and currently, plant sources are considered preferable choices. Our previous report has shown that the chloroform extract of Corchorus capsularis L. leaves exhibits a significant effect against Leishmania donovani promastigotes. In the current study, bioassay-guided fractionation results for Corchorus capsularis L. leaf-derived β-sitosterol (β-sitosterol_CCL) were observed by spectroscopic analysis (FTIR, ¹H NMR, ¹³C NMR and GC-MS). The inhibitor

SUBMITTER: Pramanik PK 

PROVIDER: S-EPMC7686382 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature