The Lung Microbiome of Three Young Brazilian Patients With Cystic Fibrosis Colonized by Fungi.

ABSTRACT: Microbial communities infiltrate the respiratory tract of cystic fibrosis patients, where chronic colonization and infection lead to clinical decline. This report aims to provide an overview of the diversity of bacterial and fungal species from the airway secretion of three young CF patients with severe pulmonary disease. The bacterial and fungal microbiomes were investigated by culture isolation, metataxonomics, and metagenomics shotgun. Virulence factors and antibiotic resistance genes were also explored. A. fumigatus was isolated from cultures and identified in high incidence from patient sputum samples. Candida albicans, Penicillium sp., Hanseniaspora sp., Torulaspora delbrueckii, and Talaromyces amestolkiae were isolated sporadically. Metataxonomics

SUBMITTER: de Almeida OGG 

PROVIDER: S-EPMC7686462 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature