Characterization of dysregulated glutamine metabolism in human glioma tissue with ¹H NMR.

ABSTRACT: Gliomas are one of the most common types of brain tumors. Given low survival and high treatment resistance rates, particularly for high grade gliomas, there is a need for specific biomarkers that can be used to stratify patients for therapy and monitor treatment response. Recent work has demonstrated that metabolic reprogramming, often mediated by inflammation, can lead to an upregulation of glutamine as an energy source for cancer cells. As a result, glutamine pathways are an emerging pharmacologic target. The goal of this pilot study was to characterize changes in glutamine metabolism and inflammation in human glioma samples and explore the use of glutamine as a potential biomarker. ¹H high-resolution magic angle spinning nuclear magnetic resonance spectra were acquired from e

SUBMITTER: Ekici S 

PROVIDER: S-EPMC7686482 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature