ADORA2A variation and adenosine A₁ receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.

ABSTRACT: Adenosine, its interacting A₁ and A_2A receptors, and particularly the variant rs5751876 in the A_2A gene ADORA2A have been shown to modulate anxiety, arousal, and sleep. In a pilot positron emission tomography (PET) study in healthy male subjects, we suggested an effect of rs5751876 on in vivo brain A₁ receptor (A₁AR) availability. As female sex and adenosinergic/dopaminergic interaction partners might have an impact on this rs5751876 effect on A₁AR availability, we aimed to (1) further investigate the pilot male-based findings in an independent, newly recruited cohort including women and (2) analyze potential modulation of this rs5751876 effect by additional adenosinergic/dopaminergic gene variation. Healthy volunteers (32/1

SUBMITTER: Hohoff C 

PROVIDER: S-EPMC7686488 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature