Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease Severity.

ABSTRACT: Disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild illness to severe respiratory disease and death. In this study, we determined the kinetics of viral loads, antibody responses (IgM, IgG, neutralization) and SARS-CoV-2-specific CD4 T cells by quantifying these parameters in 435 serial respiratory and blood samples collected from a cohort of 29 COVID-19 patients with either moderate or severe disease during the whole period of hospitalization or until death. Remarkably, there was no significant difference in the kinetics and plateau levels of neutralizing antibodies among the groups with different disease severity. In contrast, the dynamics of specific CD4 T cell responses differed considerably, but all patients with moderate or severe diseas

SUBMITTER: Koblischke M 

PROVIDER: S-EPMC7686651 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature