The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome.

ABSTRACT:

Objectives

Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but breakpoints of target attainment are mostly based on expert opinions. Studies that show a correlation between target attainment and infection resolution are missing. This analysis investigated whether there is a difference in infection resolution based on two breakpoints of target attainment.

Methods

An outcome group out of 1392 critically ill patients treated with meropenem or piperacillin-tazobactam was formed due to different selection criteria. Afterwards, three groups were created: group 1=free drug concentration (f) was < 100% of the time (T) above the minimal inhibitory concentration (MIC) (< 100% fT > _MIC), group 2=100% fT > _MIC < _4xMIC, and group

SUBMITTER: Scharf C 

PROVIDER: S-EPMC7686672 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature