Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease.

ABSTRACT: Extensive effort has been made studying retinal pathology in Alzheimer's disease (AD) to improve early noninvasive diagnosis and treatment. Particularly relevant are vascular changes, which appear prominent in early brain pathogenesis and could predict cognitive decline. Recently, we identified platelet-derived growth factor receptor beta (PDGFRβ) deficiency and pericyte loss associated with vascular Aβ deposition in the neurosensory retina of mild cognitively impaired (MCI) and AD patients. However, the pathological mechanisms of retinal vascular changes and their possible relationships with vascular amyloidosis, pericyte loss, and blood-retinal barrier (BRB) integrity remain unknown. Here, we evaluated the retinas of transgenic APP_SWE/PS1_ΔE9 mouse models of AD (ADtg

SUBMITTER: Shi H 

PROVIDER: S-EPMC7686701 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature