PD-1/PD-L1 expression profiles within intrahepatic cholangiocarcinoma predict clinical outcome.

ABSTRACT:

Objective

Immunotherapy targeting the programmed cell death protein-1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) pathway has been observed to be efficient in several solid tumors. We aim to investigate the prognostic significance of PD-1/PD-L1 expression profile in intrahepatic cholangiocarcinoma (ICC).

Materials and methods

We investigated the expression of PD-1, PD-L1, CD8⁺ T cells, and CD68⁺ macrophages in paired tumor and adjacent normal tissues from 322 ICC patients using tyramide signal amplification (TSA)-based multiplexed immunohistochemistry.

Results

We found that high proportion of tumor-infiltrating CD8⁺ PD-1^High within CD8⁺ PD-1⁺ T cells significantly correlated with advanced TNM

SUBMITTER: Tian L 

PROVIDER: S-EPMC7686719 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature